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Beta 1 Blockers Vs. Beta 2 Blockers

There are several different types of beta blockers. Each has a different action and effect on the body. Though commonly prescribed, they should not be taken lightly. Interactions with other drugs and diseases need to be recognized.

  1. How Beta Blockers Work

    • Most beta blockers simply block beta receptors found in the body. Some mimic the affect of a receptor making its action unnecessary. .

    Beta Receptors

    • When referring to beta 1 and beta 2 blockers, It is not the blockers that are 1 and 2, but the receptors they are blocking. There are actually three types of beta receptors. Beta 1 receptors are found in the heart and brain. Beta 2 receptors are found in the gastrointestinal tract, uterus, vascular smooth muscles, lungs, and skeletal muscles. Beta 3 receptors are found in fat cells.

    Non-Selective Beta Blockers

    • These are first-generation beta blockers. They will block some of both beta 1 and beta 2 receptors. They can slow not only cardiac output, but also the renal and other systems. You may lower your blood pressure but risk kidney or breathing problems.

    Selective Beta Blockers

    • Second-generation beta blockers are selective. They block beta 1 receptors and are very useful in hypertension and certain cardiac diseases. They relax the heart and slow its pumping, thus lowering blood pressure and heart rate. This allows the mechanism of the heart to improve over time.

    Drug Interactions

    • Beta blockers can interact with certain medication and supplements in a negative way. When taken with anti-depressants there can be a dangerous drop in blood pressure. Anti-inflammatory drugs can counteract the benefits of beta blockers on hypertension

    Side Effects

    • As with any drugs there are always side effects listed. Some of the side effects of beta blockers include stomach cramps, dizziness, headache, depression and rash.

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