What is a normal hemoglobin AA sequence?

The normal hemoglobin A sequence (also called Hb A0 or Hb A) consists of four polypeptide chains: two alpha chains and two beta chains. Each chain is composed of a specific sequence of amino acids.

The alpha chain of Hb A contains 141 amino acids and has the following sequence:

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VLSPADKTNVKAAWGKVGAHAGEYGAEALERMFLSFPTTKTYFPHFDLSHGSAQVKGHGKKVADALTNAVAHVDDMPNALSALSDLHAHKLRVDPVNFKLLSHCLLVTLAAHLPAEFTPAVHASLDKFLASVSTVLTSKYR

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The beta chain of Hb A contains 146 amino acids and has the following sequence:

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VHLTPEEKSAVTALWGKVNVDEVGGEALGRLLVVYPWTQRFFESFGDLSTPDAVMGNPKVKAHGKKVLGAFSDGLAHLDNLKGTFATLSELHCDKLHVDPENFRLLGNVLVCVLAHHFGKEFTPPVQAAYQKVVAGVANALAHKYH

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These sequences represent the primary structures of the alpha and beta chains of Hb A. The complete hemoglobin molecule is formed by the assembly of these chains into a tetrameric structure.

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