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Signs & Symptoms of Clarkson Disease

Clarkson's disease is also known as systemic capillary leak syndrome. According to the Mayo Clinic, this is an extremely rare disease of the circulatory system, characterized by the increased size of the pores in the body's capillaries. These pores allow blood to leak from the circulatory system and into the body. The symptoms of the disease mimic other ailments, which could result in misdiagnosis.

  1. Low Blood Pressure

    • The initial symptom of Clarkson's disease is a low blood-pressure rate, but not all people with low blood pressure have Clarkson's disease. The leakage of blood into the body cavity depletes the vacuum of the circulatory system, causing the pressure of the system to be seriously affected. This condition is also known as hypotension.

    Hemoconcentration

    • Hemoconcentation is a blood condition in which the liquid content of the blood has been depleted due to a loss of plasma. Plasma is the liquid that carries the blood cells through the body. While the blood cells remain in the bloodstream, the actual liquid that carry them has been depleted. The result is an increased concentration in red blood cells and the aforementioned hypotension.

    Hypoalbuminemia

    • Hand in hand with the hypotension and hemoconcentration is a condition called hypoalbuminemia, or the loss of albumen in the bloodstream. Albumen is one of the dominant proteins of the human body, making up a majority of the protein located in blood plasma. While the depleted plasma supply concentrates the red blood cells, it loses this essential protein.

    Widespread Edema

    • One of the functions of albumen is to contain and reduce swelling in the body. The lack of this protein leads to swelling, or edema, throughout the body.

    Symptoms working together

    • While the symptoms seem to already work together, they can go a step further in more severe cases. The lack of pressure, combined with increased swelling, will lead to the collapse of some blood vessels. Kidney failure is also a concern, as depleted plasma levels restrict the amount of blood filtered through the kidneys. This reduced workload leads to tubular necrosis, or the cell death of the tubes that connect the kidneys to the urethra. The renal failure is caused by a backup of toxins in the kidneys.

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