How can cirrhosis effect the liver?
1. Scarring (Fibrosis):
* Cirrhosis causes the liver to produce scar tissue in response to injury and inflammation.
* As the scarring increases, the liver's normal architecture is disrupted.
2. Nodules (Regeneration):
* In an attempt to compensate for the damaged liver tissue, healthy liver cells regenerate and form nodules surrounded by scar tissue.
* These nodules are disorganized and impair liver function.
3. Impaired Blood Flow:
* Scar tissue blocks the flow of blood through the liver, increasing pressure in the portal vein (the vein that carries blood from the intestines to the liver).
* This is known as portal hypertension.
4. Portal Hypertension:
* Portal hypertension leads to several complications, including:
- Splenomegaly (enlarged spleen)
- Esophageal varices (enlarged veins in the esophagus that can rupture and bleed)
- Ascites (fluid accumulation in the abdomen)
5. Reduced Liver Function:
* As scarring progresses, the liver becomes less able to perform its functions, such as:
- Producing bile for digestion
- Removing toxins
- Producing clotting factors
- Regulating blood sugar