What effect does Wellbrutin have on the liver?

Wellbutrin (bupropion) is generally well-tolerated by the liver. It is metabolized in the liver by the cytochrome P450 enzyme system, primarily by the CYP2B6 isoenzyme. However, Wellbutrin does not appear to cause significant liver damage or impairment of liver function in most individuals.

In clinical studies, the incidence of liver-related side effects with Wellbutrin has been relatively low. The most common liver-related side effects reported with Wellbutrin include:

1. Mild elevations in liver enzymes (such as alanine aminotransferase [ALT] and aspartate aminotransferase [AST]). These elevations are usually transient and resolve with continued treatment.

2. Nausea and vomiting: These side effects are more common during the initial phase of treatment and typically subside over time.

3. Abdominal pain: This is a less common side effect that can occur with Wellbutrin.

Rarely, Wellbutrin can cause more severe liver damage, such as hepatitis or liver failure. However, these cases are very uncommon and typically occur in individuals with underlying liver disease or who are taking other medications that can affect the liver.

If you are concerned about the potential effects of Wellbutrin on your liver, it is important to discuss this with your doctor. Your doctor can monitor your liver function and make any necessary adjustments to your treatment plan.