What Are the Causes of High Cortisol?

Cortisol is a hormone secreted by the adrenal glands. It supports the body's metabolism and helps the body manage stress. According to the University of Michigan Health System, many conditions can affect cortisol levels.

Stress

• Because the adrenal glands secrete cortisol in response to stress, a common cause of high cortisol is prolonged stress.

Cushing's Syndrome

• A high cortisol level in the blood might indicate Cushing's Syndrome, a condition potentially caused by overactive adrenal glands, a pituitary or adrenal gland tumor, some types of cancer, or long-term use of corticosteroids.

Disease

• Other conditions that can cause a high cortisol level are severe liver or kidney disease, depression, hyperthyroidism (overactive thyroid gland) or obesity. Also, recent surgery, illness, injury or infection can cause high cortisol levels.

Pregnancy

• Pregnancy or birth control pills can cause a high blood cortisol level.

Inflammation

• According to Dr. Diana Schwarzbein, cortisol is important for controlling inflammation in the body so chronic inflammation can also lead to high cortisol levels.