Is the hormones affected after myomectomy?

Yes, a myomectomy can affect hormone levels.

Uterine fibroids, also known as leiomyomas, are noncancerous growths that develop in the muscular wall of the uterus. They are the most common benign tumours in women of reproductive age, affecting up to 70% of women. Myomectomy is a surgical procedure to remove uterine fibroids while preserving the uterus. Hormones produced by the ovaries, such as estrogen and progesterone, play a role in the development and growth of uterine fibroids. Estrogen and progesterone levels can be altered following myomectomy, which may affect a woman's menstrual cycle and fertility.

After a myomectomy, the following hormonal changes may occur:

1. Estrogen and Progesterone Levels: The ovaries are the primary source of estrogen and progesterone, which are responsible for regulating the menstrual cycle and fertility. During pregnancy, the placenta also produces these hormones. Myomectomy can disrupt the normal production and release of estrogen and progesterone, which may lead to changes in menstrual patterns, such as irregular or heavy bleeding.

2. Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH): FSH and LH are hormones produced by the pituitary gland that regulate the menstrual cycle and ovulation. After a myomectomy, the levels of FSH and LH may increase, which can stimulate the ovaries to produce more estrogen and progesterone. This can result in changes in the timing of ovulation, making it more difficult to predict when a woman is most fertile.

3. Prolactin: Prolactin is a hormone produced by the pituitary gland that stimulates milk production during breastfeeding. In some cases, myomectomy can cause an increase in prolactin levels, which may lead to breast milk production or other symptoms associated with high prolactin levels, such as irregular menstrual cycles and infertility.

4. Thyroid Hormones: Myomectomy can also affect the production of thyroid hormones, which play a vital role in metabolism and overall health. Changes in thyroid hormone levels may lead to symptoms such as fatigue, weight gain or loss, and changes in mood.

It is important to note that the hormonal effects of myomectomy can vary from woman to woman. Some women may experience significant changes, while others may have minimal or no changes. The impact of myomectomy on hormone levels is also influenced by factors such as the number and location of fibroids, the surgical approach used, and the woman's individual response to the procedure. Post-operative hormone replacement therapy may be necessary in some cases to manage symptoms and restore hormonal balance.