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Estrogen Patch Vs. Pill

Since the Women's Health Initiative study published in 2002 showed a marked increase in the risk for breast cancer, blood clots, and deep vein thrombosis for women undergoing hormone replacement therapy, many women are taking a second look at their options.

  1. Active Ingredients

    • The usual pill given for hormone replacement therapy (HRT) contains synthetic estrogen in a norpregnane form (carbon-18 and -19 molecules have been removed). The patch contains synthetic estrogen with the carbons intact (pregnane), along with micronized progesterone.

    Effectiveness

    • Both forms are effective for treating menopausal symptoms like hot flashes, vaginal dryness and night sweats, according to FDA.gov.

    Side Effects

    • Oral synthetic estrogen was found by the Women's Health Initiative to be a significant risk factor in the development of breast cancer, blood clots and deep vein thrombosis. The Estrogen Thromboembolism Risk study (ESTHER), conducted in France by M. Canonico PhD et al, showed that the transdermal pregnane form of estrogen does not appear to be a risk factor.

    Convenience

    • For some women the patch, which is only replaced weekly, may seem to be more convenient than a daily pill.

    Considerations

    • You should discuss all your hormone replacement therapy options with your doctor.

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