Definition of Leukotriene Synthesis
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Classification
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Leukotrienes are classified into two types: cysteinyl and non-cysteinyl. Cysteinyl leukotrienes include C4, D4 and E4, while the non-cysteinyl leukotriene is B4.
Synthesis
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The synthesis of leukotrienes follows a linear pathway initially catalyzed by the action of a specific enzyme, lipoxygenase. The arachidonic acid serves as the raw material and the leukocytes as the primary synthesizer.
Significance
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Leukotrienes play an important role in the immune defense of the body. They mediate inflammation in atherosclerosis and aid in blood clotting.
Diseases
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Diseases such as asthma and allergy are brought about by the overproduction of leukotrienes, particularly cysteinyl leukotrienes. On the other hand, the non-cysteinyl leukotriene B4 is likely to cause chronic inflammation.
Treatment
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The asthma medication, Zyflo, works by inhibiting the synthesis of leukotriene. Medications like Singulair and Accolate interfere with leukotriene-receptor interactions.
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