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Drugs That Reduce Testosterone in Males

Commonly when the issue of hormones are considered, it is in the context of females and whether or not to initiate hormone replacement therapy. However, hormone levels can be an important issue for males as well, and drugs can be used to lower testosterone levels in men.

  1. Why?

    • The American Cancer Society states that testosterone can actually make prostate cancer grow. Lowering testosterone levels can shrink and slow the growth of prostate cancer in some patients.

    LHRH Analogs

    • Luteinizing hormone-releasing hormone drugs (LHRH analogs) work by reducing the amount of testosterone made by the testicles via injection or small patch. Initially, the levels will rise before dropping significantly.

    GnRH Antagonists

    • Drugs.com states that gonadotropin-releasing hormone (GnRH) antagonists, such as degarelix, work by lowering the amount of testosterone in the blood. The drug is injected.

    Side Effects

    • The side effects of testosterone-lowering drugs include but are not limited to decreased sex drive, high blood pressure, dizziness, nausea, constipation, pain while urinating and rapid heartbeat. Contact your doctor if these persist.

    Estrogen and Anti-Androgens

    • In the past, estrogen (the female hormone) was commonly used to lower testosterone; however, it is rarely used because of its side effects. Anti-androgens prevent the body from using any type of androgens (male hormones).

    Caution

    • These drugs carry with them side effects that vary from patient to patient. Consult your physician and educate yourself on all of the available treatments before deciding on one.

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