Reasons for Low Protein in a Blood Serum Test

Protein levels are commonly assessed when determining the individual’s nutritional status. More precisely, these indicators help evaluate the degree of protein-energy malnutrition (PEM), which typically accompanies acute illness or trauma. They can also assist in diagnosis of specific diseases.

Rationale

• Physiological insults initiate inflammation and increase energy and protein demands. In response, the body shifts away from protein synthesis and more towards catabolism, thereby decreasing concentrations of various blood proteins. These concentrations are reflective of the severity of illness or injury. Serum protein levels are also indicative of overall nutritional status, with or without physiological stress.

Proteins sampled

• Blood protein indicators can be subdivided into two distinct categories: negative acute-phase respondents and positive acute-phase respondents. The negative respondents such as albumin decrease during the inflammatory response. Conversely, positive respondents like various globulins tend to rise under inflammatory stress.

Interpretation

• Depressed acute-phase protein readings may indicate a hypermetabolic, inflammatory state, as would occur with trauma, infection, or autoimmune disease. It may also be associated with inadequate protein-energy intake or malabsorption. Hyperthyroidism, Hodgkin’s lymphoma, as well as certain forms of kidney and liver disease may also depress values.

Test limitations

• Protein levels are subject to numerous influences which can lead to misinterpretation of results. Low levels of zinc, iron, or vitamin A, numerous hormonal medications, and prolonged immobilization are just some of the factors that can affect measurements.

Warning

• This article is for informational purposes only and is no way intended for medical diagnosis.