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The Side Effects of INH

Isoniazid is an antibiotic prescribed to prevent tuberculosis in high-risk patients, and with other drugs to eliminate existing tuberculosis. Technically known as isonicotinic acid hydrazide, isoniazid is commonly called INH. It is available in generic form or as the brand Niazid. Many side effects are possible, some serious.

  1. Common Side Effects

    • The most common side effects associated with INH are heartburn, upset stomach, nausea and dizziness. These effects usually are temporary.

    Liver Damage

    • INH is linked to severe liver problems such as hepatitis and liver issues are the primary reason patients stop taking this drug. The risk increases with age and with alcohol use.

    Allergic Reactions

    • Although uncommon, some people experience an allergic reaction to INH. Signs are hives, difficulty breathing, throat closing and facial or mouth swelling.

    Other Side Effects

    • Other serious side effects can include peripheral neuropathy (nerve damage in the hands and feet), blurred vision or changes in color vision, swollen lymph nodes, reductions in white blood cells or platelets, high blood sugar, difficulty urinating and seizures.

    Drug Interactions

    • Many drugs interact with INH, which may strengthen or weaken the effects of INH or the other drug. These drugs include anticoagulants, caffeine, corticosteroids, certain types of antidepressants, and medication for diabetes and for Parkinson's disease.

    Food Interactions

    • Many foods also interact with INH, including certain types of cheese and meat, but not all patients experience this interaction. Effects include severe headaches, vomiting, diarrhea and irregular heartbeat.

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