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Side Effects of Flagyl

Flagyl, or metronidazole, is an antimicrobial agent used to treat infections caused by protozoan or anaerobic bacterial pathogens. Flagyl is used to treat certain gastrointestinal and genitourinary conditions, and is considered a first-line treatment for pseudomembranous colitis, a serious opportunistic bowel infection. Flagyl is also used in combination with other drug products as part of a regimen to eradicate Helicobacter pylori, a bacterial species responsible for certain types of ulcers.
Metronidazole, the active ingredient in Flagyl, is found in a variety of forms, including oral, intravenous and topical. It may be used to treat skin and soft-tissue conditions via topical application in cream, lotion and gel vehicles.
As with any medication, users may experience side effects.

  1. Gastrointestinal/Hepatic Effects

    • Nausea, vomiting, diarrhea and loss of appetite may occur in greater than 10 percent of patients taking Flagyl by mouth. Metallic taste, other altered-taste sensations or dry mouth may occur in 1 percent to 10 percent of patients whether Flagyl is taken by mouth or absorbed via vaginal application. Both oral and vaginal application may induce vomiting, flushing and/or rapid heartbeat if alcohol is consumed during use. Though this effect is rare, it is best to avoid alcoholic beverages and products that contain alcohol (mouthwash, cough syrup, etc.) while using Flagyl. Flagyl should be used in caution in patients with decreased liver function as drug concentration may build up to higher than desired levels.

    Genitourinary Effects

    • Flagyl may cause darkening of urine in 1 percent to 10 percent of patients, but this effect has not been shown to be harmful. Painful urination, crystallization of the urine and increased urination have also been recorded. Vaginal yeast infection with Candida organism(s) has been reported with both oral and vaginal administration of metronidazole.

    Dermatologic Effects

    • Skin rash, itching or flushing may occur.

    Central Nervous System Effects

    • Seizures and numbness in the extremities have been reported with prolonged use of Flagyl, but are rare. Movement difficulties, weakness, insomnia, irritability, decreased libido, unexplained fever and depression have also been noted.

    Other Important Information

    • Flagyl should be taken with a full glass of water. Alcohol intake should be avoided if possible, and numbness, tingling, seizures or extreme pain should be reported to a physician right away. The entire course of therapy should be finished unless your physician directs otherwise. Though empty-stomach administration is preferred, Flagyl make be taken with food to minimize stomach upset.

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