Can you have fever and no infection?

Yes, it is possible to have a fever without an infection. Fever is a symptom that indicates an elevated body temperature, usually above the normal range of 36.5 to 37.5 degrees Celsius (97.7 to 99.5 degrees Fahrenheit). While fever is often associated with infections caused by bacteria or viruses, there are several non-infectious conditions that can also lead to a fever. Some examples of such conditions include:

1. Inflammatory disorders: Certain inflammatory conditions, such as autoimmune diseases (e.g., rheumatoid arthritis, lupus), vasculitis (inflammation of blood vessels), or inflammatory bowel disease can cause fever. In these conditions, the body's immune system is overactive and produces inflammatory substances that can lead to an increase in body temperature.

2. Malignancies (cancers): Some types of cancers, especially blood-related cancers like leukemia and lymphoma, can cause fever. The presence of cancer cells in the body can disrupt the normal regulation of body temperature.

3. Drug reactions: Certain medications can cause a fever as a side effect. These reactions are usually short-term and resolve once the medication is discontinued.

4. Heatstroke: Prolonged exposure to extremely high temperatures, such as in heat waves, can lead to heatstroke. Heatstroke occurs when the body's natural cooling mechanisms are overwhelmed and the body temperature rises rapidly.

5. Dehydration: Severe dehydration can also cause a rise in body temperature, especially in young children and the elderly. Dehydration affects the body's ability to regulate temperature and can lead to a fever.

6. Thyroid disorders: Hyperthyroidism, a condition in which the thyroid gland is overactive, can sometimes cause a fever.

7. Central nervous system disorders: Damage to certain areas of the brain, such as the hypothalamus, which is responsible for regulating body temperature, can lead to fever.

8. Factitious fever: In rare cases, a person may intentionally induce fever in themselves or someone else, known as factitious fever. This condition is usually associated with psychological or emotional problems.

It's important to note that fever is a nonspecific symptom, and the underlying cause may not always be immediately apparent. If you have a persistent fever without any obvious signs of infection or other known causes, it's recommended to consult a healthcare professional for proper evaluation and diagnosis.

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