What are three ways bacteria may win the battle against phages?

1. Restriction-Modification (RM) Systems: Bacteria can possess RM systems that act like cellular security scissors. They recognize and cut up foreign DNA, such as that of invading phages, by targeting specific patterns called restriction sites. Meanwhile, the bacteria's own DNA remains protected by modifications like methylation that prevent self-destruction.

2. CRISPR-Cas Systems: These are sophisticated immune systems found in many bacteria and archaea. They function like adaptive memory banks for previous phage encounters. CRISPR-Cas systems can generate short RNA molecules that match the genetic sequence of encountered phages. These RNAs guide the Cas proteins to precisely target and destroy any future phage DNA that bears that specific sequence.

3. Abortive Infection (Abi) Systems: Some bacteria use Abi systems as a quick-response defense mechanism. When a phage injects its DNA, Abi triggers a rapid self-destruction program within the bacterial cell, aborting the infection before phage replication can even begin. This strategy prevents progeny phages from forming, effectively cutting the infection cycle short.