How did celiac disease start?

Celiac disease is an autoimmune disorder that is triggered by eating gluten, a protein found in wheat, barley, and rye. It is thought to be caused by a combination of genetic and environmental factors.

Genetics

Celiac disease is strongly linked to certain genes, including HLA-DQ2 and HLA-DQ8. These genes are responsible for producing proteins that help the immune system distinguish between the body's own tissues and foreign substances. In people with celiac disease, these proteins are unable to properly recognize gluten, and the immune system attacks the lining of the small intestine, causing inflammation and damage.

Environmental factors

Gluten exposure is the main environmental trigger for celiac disease. However, it is not known exactly what causes some people with the genetic risk factors to develop the disease while others do not. Some possible factors include:

* Early exposure to gluten: Some studies have shown that early exposure to gluten, such as through breast milk or infant formula, may increase the risk of celiac disease.

* Intestinal infections: Certain intestinal infections, such as rotavirus, may also increase the risk of celiac disease.

* Stress: Stress can trigger celiac disease in people who are already genetically predisposed to the condition.

It is important to note that celiac disease is not contagious. It is a chronic condition, but it can be managed with a gluten-free diet.