Can azathioprine can cause Renal damage?

Yes, azathioprine can cause renal damage.

Azathioprine is an immunosuppressive drug that is used to treat a variety of conditions, including rheumatoid arthritis, Crohn's disease, and ulcerative colitis. It works by suppressing the immune system, which can help to reduce inflammation and improve symptoms.

However, azathioprine can also cause a number of side effects, including renal damage. Renal damage can occur in up to 2% of people who take azathioprine. It is more common in people who take high doses of the drug or who have been taking it for a long period of time.

Renal damage caused by azathioprine can range from mild to severe. In mild cases, it may only cause a slight increase in creatinine levels. In severe cases, it can lead to kidney failure.

Risk factors for developing renal damage from azathioprine include:

- Older age

- Diabetes

- Hypertension

- Heart disease

- Liver disease

- Taking other medications that can damage the kidneys

If you are taking azathioprine, it is important to have your kidney function monitored regularly. Your doctor will order blood tests to check your creatinine levels and may also order a urine test to check for proteinuria. If you develop any symptoms of renal damage, such as swelling in your feet, ankles, or hands; unexplained weight gain; or decreased urine output, it is important to see your doctor right away.

Renal damage caused by azathioprine can usually be reversed if the drug is stopped early. However, in some cases, it can lead to permanent kidney damage.