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What Can Effect a PSA Reading?

A PSA reading is a measurement of the prostate-specific antigen, which is a protein found in the prostate cells. This level is obtained by a blood draw. Certain factors and medications can alter a PSA level.

  1. Abnormal Levels

    • PSA levels above normal indicate prostate cancer, prostatitis or benign prostatic hypertrophy (BPH). If your PSA level is elevated, your physician will perform further testing to determine the cause of your elevation.

    Medications

    • Certain medications such as diethylstilbestrol (DES) and finasteride (Proscar, Propecia) can decrease PSA levels. Your physician will tell you if you need to hold these medications before having your PSA level drawn.

    Examinations

    • A PSA level should be drawn before or several hours after a digital rectal examination to avoid a slightly raised PSA level. A digital rectal examination is performed to check the prostate gland for abnormalities.

    Procedures

    • A PSA level should be drawn before or six weeks after a transurethral resection of the prostate (TURP) or prostate biopsy because these procedures can elevate a PSA level.

    Infections

    • A urinary tract infection (UTI) or prostatitis can elevate a PSA level as much as five times the normal level for up to six weeks.

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