About Mesalamine Treatment

Mesalamine is a prescription anti-inflammatory drug. It is most commonly used for people with digestive issue such as Crohn's Disease or ulcerative colitis. Mesalamine was designed so it will work specifically and only in the gut. It is sold as the brand names Pentasa, Rowasa, Canasa and Asacol.

Function

• Mesalamine works by lowering inflammation in the large intestine. Diseases such as ulcerative colitis create chemicals called prostaglandins, which are produced by enzymes that those with digestive disorders overproduce. Mesalamine blocks the production of these enzymes. Mesalamine is prescribed in both a tablet form, capsules and as a rectal enema and suppository. These suppositories are only used when the rectum is involved. Sometimes benefits can be seen in as soon as three days of taking the medication, but usually it will be a few weeks for mesalamine to start being effective.

Side Effects

• Headaches and excessive flatulence are the most common side effects of taking mesalamine. Itchy skin and loss of hair are also common. Other, less frequent side effects include fatigue, back pain, disorders of the blood, pancreatitis, heart issues and acne. Your doctor should evaluate your kidney health before prescribing mesalamine since kidney dysfunction has been associated with the drug. People with an intolerance to aspirin or sulfates should also avoid taking mesalamine.

Other Precautions

• Pregnant and nursing mothers should do research before taking mesalamine. Though animal studies proved that mesalamine did not harm the fetus, there is not enough human data to be sure of this fact. Since mesalamine is excreted in breast milk, a nursing mother should discuss the risks with a doctor. People taking ibuprofen and other non-steroidal anti-inflammatory drugs should not take mesalamine since the combination can damage the kidneys.

Mesalamine Oral

• It is important to take mesalamine orally just as the doctor prescribes. You should take it with a full glass of water. It can usually be taken with or without food. Some brands, such as Lialda, are extended-release tablets and should be taken with a meal. The pills should be swallowed whole. If you overdose, contact your doctor immediately.

Mesalamine Rectal

• For the best results, it is recommended you empty your bowels before using mesalamine rectal enemas or suppositories. Doctors will prescribe different doses per patient, depending on the disorder and the size of the patient. It is important to read directions thoroughly. When using the enema, expect to be laying down for at least 30 minutes for the medicine to properly distribute through the body.