What is indicated by Elevated C-Reactive protein and RDW?

Elevated C-reactive protein (CRP) and Red cell distribution width (RDW) are two laboratory findings that can indicate inflammation and red blood cell abnormalities, respectively.

C-reactive protein:

- CRP is a protein produced by the liver in response to inflammation.

- Elevated CRP levels are a sign of systemic inflammation, which can be caused by various conditions such as infections, autoimmune disorders, injuries, and chronic diseases.

- A high CRP level indicates the presence of an inflammatory process in the body and can be used to monitor the severity and progression of certain diseases.

Red cell distribution width:

- RDW is a measure of the variation in the size of red blood cells in a sample.

- An elevated RDW (high RDW) indicates that there is a wider range of red blood cell sizes than normal. This can be caused by several factors, including:

- Iron deficiency anemia: A condition in which the body does not have enough iron to produce healthy red blood cells.

- Thalassemia: A genetic blood disorder that affects the production of hemoglobin, the oxygen-carrying protein in red blood cells.

- Sickle cell anemia: A genetic blood disorder in which red blood cells become sickle-shaped and can cause severe complications.

- Inflammation: Certain inflammatory conditions can lead to an increase in RDW, as the body produces larger and smaller red blood cells in response to the inflammation.

The combination of elevated CRP and RDW can suggest an inflammatory process accompanied by abnormalities in red blood cell production or function. Further evaluation and specific diagnostic tests may be needed to determine the underlying cause and provide appropriate treatment.