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The Function of the TCA Cycle

Our body's cells must produce a constant supply of energy for our survival. One major method of energy production is the tri-carboxylic acid cycle. The TCA cycle, also known as the Krebs' Cycle because of Hans A. Krebs who discovered it in 1937, is a complex chemical process that plays a vital role in the overall health of the human body.

  1. What is the TCA Cycle?

    • The TCA cycle is a metabolic pathway that occurs within cells to break down carbohydrates, fat and protein into usable energy, according to Ward Dean and Jim English of "Nutrition Review." The TCA cycle takes place in the mitochondria, the energy producing area of the cell. The mitochondria requires oxygen in order to carry out the TCA cycle.

    Function

    • The primary function of the TCA cycle is to produce the large amount of energy required to keep the human body alive and functioning properly. The end result of each cycle is the production of 38 adenosine triphosphate molecules, which provide energy for carrying out cellular functions. Dean and English emphasize that the human body cannot survive without a supply of ATP.

    Significance

    • Deficiency or disruption of the TCA cycle inhibits normal energy production and can lead to a variety of metabolic symptoms and disorders, including fatigue, muscle pain, immune system dysfunctions, even depression and dementia, according to Dean and English. Proper diet and taking supplements that support the TCA cycle can help to relieve irregularities. Your doctor can diagnose improper functioning of the TCA cycle and recommend appropriate supplements.

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