What is the difference between localized and systemic scleroderma?
Localized scleroderma:- Also called morphea
- Affects only the skin
- Can cause skin to become hard, thick, and discolored
- May also cause itching and pain
- Most common in children and young adults
- Usually treated with topical medications, such as corticosteroids or calcipotriene
- Prognosis is generally good, with most people experiencing complete remission within a few years
Systemic scleroderma:
- Also called scleroderma or progressive systemic sclerosis (PSS)
- Affects the skin, internal organs, and blood vessels
- Can cause skin to become hard, thick, and discolored
- May also cause joint pain, muscle weakness, fatigue, and shortness of breath
- Most common in women between the ages of 30 and 50
- Usually treated with systemic medications, such as corticosteroids, methotrexate, or mycophenolate mofetil
- Prognosis is variable, but most people with systemic scleroderma can live a normal life with treatment
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