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Rebif Side Effects and Throat Swelling

Rebif® (interferon beta-1a) is a prescription-only, injectable medication manufactured jointly by EMD Serono, Inc. It is approved by the FDA for individuals suffering from relapsing forms of Multiple Sclerosis (MS). It is used to help mitigate the symptoms of MS, slow its progression, and to help prevent relapses. As with many medications, Rebif® may cause side effects in some individuals, ranging from mild to severe. Tongue and throat swelling can be associated with a rare allergic reaction from this medication.
    • Injectable Medication, and Syringe with Needle

    Common Side Effects

    • According to the manufacturer, common side effects of Rebif® include pain and swelling at the injection site, and flu-like symptoms including body aches, sore throat and fatigue.

    Less Common Side Effects

    • Less common side effects include stomach or chest pain, fever, muscle spasms, difficulty swallowing, back pain and difficulty with urination.

    Throat Swelling or Difficulty Breathing

    • Although rare, an allergic reaction to interferon beta-1a can cause breathing difficulty and/or swelling of the face, tongue or throat. If you experience any of these, you should get emergency medical help immediately. Keep in mind that swelling of the throat can also be caused by other medications you are taking, foods you eat, or something in the environment. If you have any history of allergies, you should let your doctor know before taking Rebif®.

    Milder Allergic Reactions

    • Milder allergic reactions can include skin rash, dizziness, or lightheadedness. You should report milder reactions to your doctor as soon as possible.

    Additional Warnings

    • It is possible for Rebif® to have an adverse effect on liver function, thyroid function, red blood cell count, seizure activity and depression (especially in individuals with a history of these conditions. Your doctor will monitor these if interferon beta-1a is prescribed for you. Pregnant and breast-feeding women should not use this medication.

    Reporting Side Effects

    • In addition to contacting their doctor, patients who experience adverse side effects may report them to the U.S. Food and Drug Administration (FDA) at their "Medwatch" website. This reporting is voluntary, but can help the FDA in their efforts improve product safety.

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