What are the first symptoms of syndrome?

The initial signs and symptoms of Down syndrome may include:

* Distinctive facial features, including a flattened bridge of the nose, an upward slant to the eyes, and a large tongue that may protrude from the mouth

* Short stature

* Hypotonia, or decreased muscle tone

* Broad hands with a single palmar crease

* A wide gap between the big toe and the second toe

* Excessive skin at the nape of the neck