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Lithium & Parkinson's Disease

Parkinson's disease (PD) is a progressive, neurodegenerative disorder characterized by limb rigidity, lack of balance, impaired movement, and tremors. The impairment and death of dopamine cells results in the development of PD which impairs motor, speech and neurological functions. Studies have demonstrated the potential beneficial effects of lithium treatment for PD.

  1. Key Proteins

    • Bcl-2 is a protein that works to protect brain cells from injury. High levels of the protein glycogen synthase kinase 3b (GSK-3b) adversely affect brain cells and contribute to their deterioration.

    Benefits of Lithium Treatment

    • Studies have demonstrated that lithium is beneficial for protecting brain cells from premature death. Lithium has been shown to increase concentrations of Bcl-2 and reduce levels of GSK-3b.

    Lithium Toxicity

    • Toxicity occurs when lithium levels in the body become too high. Individuals with lithium toxicity may experience symptoms that include vomiting, diarrhea and muscle weakness.

    Drug Interaction

    • Medications including non-steroidal anti-inflammatory drugs (NSAIDs), diuretics, and selective serotonin reuptake inhibitors (SSRIs) can adversely interact with lithium.

    Side Effects

    • Common side effects associated with prolonged lithium use include increased thirst, either increased or decreased urination, bloating and mild nausea. Severe side effects include slurred speech, impaired vision and tremors and could be indicative of lithium toxicity.

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