The Effect of Aceclofenac on Kidney Function

Aceclofenac is a nonsteroidal anti-inflammatory drug used for pain management. Doctors often prescribe it to patients suffering from inflammation due to rheumatoid arthritis, osteoarthritis and ankylosing spondylitis. It works as a cytokine inhibitor, and is not recommended for individuals who have a history of stomach, liver or renal (kidney) problems.

Renal Function

• Aceclofenac can increase water retention.

  Aceclofenac should not be given to patients who have a history of kidney failure or malfunction. In some patients, aceclofenac reduces kidney function and increases sodium and water retention. Most NSAIDs (nonsteroidal anti-inflammatory drugs) have been associated with adverse renal reactions.

How it Works

• Aceclofenac alters blood flow to the kidneys.

  Aceclofenac alters the blood flow in your kidneys. Prostaglandins usually control the process. Prostaglandins cause vasodilation of the afferent arterioles of the glomeruli. Normal glomeruli filtration is an indicator of healthy renal function. With altered glomeruli filtration, renal failure can be detected.

Testing for Complications

• A urine spot check can identify kidney failure.

  When taking aceclofenac, the patient should check regularly with a doctor about his kidney function. Kidney problems usually develop slowly and can be monitored. Routine blood and urine tests can determine a problem early on. Tests for kidney problems include a glomerular filtration rate, spot checks for protein in urine, and blood pressure measurement.

Symptoms

• Loss of appetite and nausea are symptoms of kidney failure.

  If taking aceclofenac, there are several symptoms to be aware of that may signal kidney failure. Loss of kidney function results in a loss of appetite, nausea, vomiting and a need to urinate more or less. The patient will begin to feel lethargic and may experience darkening of the skin and muscle cramps. Any of these symptoms should prompt a visit to a physician for testing.

Other Side Effects

• Most pain management drugs have negative effects after long-term use.

  Like most drugs for pain management, aceclofenac can have a variety of adverse effects. The most common side effects are abdominal pain, nausea and vomiting. Some patients experience constipation and pancreatitis. Doctors continue to search for methods of pain management that will have fewer negative effects on users.