Calcium Channel Antagonist Side Effects

Calcium channel antagonists, also known as calcium channel blockers, are a class of medications designed to treat angina (chest pain), high blood pressure and some heartbeat irregularities. Users of these products may experience a number of side effects.

The Facts

• Calcium antagonists work by blocking calcium from entering cells in blood vessel walls and in the heart. The main effect of this action is a relaxation of the blood vessels, leading to a lowering of blood pressure.

Types

• According to the Mayo Clinic, many different calcium antagonists are available, including felodipine (Plendil), amlodipine (Norvasc) and nisoldipine (Sular). They are sometimes prescribed along with other medications for high blood pressure and cholesterol.

Minor Side Effects

• Most side effects of calcium antagonists are relatively minor. They commonly include headaches, minor ankle swelling, dizziness and flushing (sudden skin redness). Swelling and bleeding of gum tissue may also occur.

Serious Side Effects

• More serious side effects include significantly slowed heartbeat, rapid or irregular heartbeat and breathing difficulties. These may be worse in individuals with heart failure.

Additional Considerations

• While minor side effects may self-correct, serious side effects require medical attention. Taking calcium antagonists with other medications can increase the chance of side effects. Eating grapefruit or drinking grapefruit juice may also increase the likelihood of complications.