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Damaging Effects of Long-Term NSAID Use

NSAIDs, or nonsteroidal anti-inflammatory drugs, are medications used primarily for the treatment of pain, arthritis and headache. Examples include aspirin, ibuprofen and naproxen. Long-term use of NSAIDs can be damaging, especially in older people.

  1. Indigestion

    • Indigestion, also called dyspepsia, is common in people taking NSAIDs for long periods. This usually causes discomfort after meals.

    Ulcers

    • Irritation of the stomach and intestinal wall leads to small erosions or ulcers in the lining of the gut.

    Bleeding

    • NSAIDs can cause bleeding in the gut that ranges from minimal to life-threatening. Bleeding is the most serious side effect of long-term NSAID use.

    Perforation

    • The lining of the gut may become so severely damaged that holes develop. This is a life-threatening complication.

    Heart Disease

    • Certain NSAIDs are associated with an increase in heart attacks and strokes. Some of these drugs have been removed from the market.

    Kidney Disease

    • Prolonged NSAID use increases the risk of kidney damage, especially when they are combined with certain blood pressure medications.

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