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Amyloidosis Symptoms

Amyloid is an abnormal protein produced in bone marrow and that can be deposited in any part of the body (localized amyloidosis) or can be widespread, affecting tissues in various parts of the body (systemic amyloidosis). In cases of systemic amyloidosis, bodily organs can undergo serious changes.

  1. Organs

    • Organs that can be affected by amyloidosis include the spleen, heart, liver, kidneys, gastrointestinal tract and nervous system.

    Common Symptoms

    • Amyloidosis symptoms vary, depending on the affected organs. Signs of the disorder can include weight loss, swelling or numbness or tingling of extremities, constipation, diarrhea, weakness, enlarged tongue, changes in the skin (easily bruised, skin thickening), purple patches surrounding the eyes, trouble swallowing, irregular heartbeat, protein in urine and fatigue.

    Primary Amyloidosis

    • Amyloidosis affecting many areas is known as primary amyloidosis. Organs and body parts that may be affected are the skin, spleen, kidneys, nerves, blood vessels, heart, liver and intestines. Primary amyloidosis generally doesn't accompany other diseases. In some cases, however, multiple myeloma may be associated with primary amyloidosis.

    Secondary Amyloidosis

    • Chronic infectious diseases are usually the prelude to secondary amyloidosis. Among them are rheumatoid arthritis, bone infections and tuberculosis. Secondary amyloidosis tends to affect the liver, spleen, lymph nodes and kidneys. When the primary disease is treated, the amyloidosis is usually halted.

    Hereditary Amyloisosis

    • Also known as familial amyloidosis, the hereditary form of this disease manifests in the heart, liver, kidneys and nerves.

    Who's At Risk?

    • Primary amyloidosis can occur in anyone. Risk factors include age (usually patients 40 and older), chronic inflammatory or infectious conditions, heredity, and in some cases, dialysis. (Some dialysis treatments don't effectively remove the larger proteins from urine, so they can build and deposit.)

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