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Nephrogenic Systemic Fibrosis Symptoms

The rare disorder nephrogenic systemic fibrosis/nephrogenic fibrosing dermopathy (NSF/NSD) has been directly linked to the contrast agent gadolinium, injected into people before a magnetic resonance imaging (MRI) scan. This life-threatening condition mainly affects people with kidney problems, although some people who were unaware of any kidney issues have developed NSF/NSD.

  1. Initial Symptoms

    • NSF/NSD typically begins with red or darkened patches or plaques on the skin that may cause burning, itching or painful sensations. They usually occur on the feet, legs, arms and hands, but may also appear on the trunk.

    Progressive Symptoms

    • Over several days to several weeks, these patches spread and progress into swollen and tight areas that may begin feeling woody or resemble the texture of an orange peel. The skin thickens and becomes dry and scaly.

    Complications from Skin Symptoms

    • Because of the hardened skin, people with severe cases of NSF/NSD may be unable to walk or extend their joints, and they experience muscle weakness. Tightness around the joints can cause people to fall and suffer fractures.

    Bodily Progression

    • Patients may feel pain in the hip bones or ribs, develop yellow raised spots on the whites of the eyes, and the disease may progress to internal organs, causing fibrosis or scarring.

    Life-Threatening Stage

    • NSF/NSD can be fatal due to complications from the disease such as restricted ventilation from lung fibrosis or effects on other organs.

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