Causes of Peyronie's Disease

Peyronie's disease is a condition where your penis bends during erection as a result of thick scar tissue under your skin. Although research continues to determine the cause, there are several theories that are being studied. In addition to your penis bending during erection, you may experience pain and, in extreme situations, erectile dysfunction.

Injury

• It is thought that injuries or trauma to your penis can cause small blood vessels to rupture. If the ruptures do not heal normally, it can cause a thick scar tissue or plaque that causes your penis to become deformed. The trauma could occur during extremely vigorous intercourse or during medical procedures such as catheterization or cystoscopy.

Autoimmune Disorder

• One theory is that Peyronie's may be caused by an autoimmune disorder in which your immune system may cause the plaque to be formed in the penis. It is not believed to be related to other autoimmune diseases.

Inherited Abnormal Collagen Condition

• According to the Mayo Clinic, it may be a genetic condition as a result of abnormal regulation of collagen.

Medications

• Peyronie's disease may be a side effect of certain medications such as beta blockers. It has been on rare occasions been caused as a result of taking an antihypertension medication called propranolol.

Risk Factors

• If you have certain conditions or diseases, you are at higher risk of developing Peyronie's disease. They include diabetes, lupus or other connective tissue disorders, and vitamin E deficiency.

Warning

• If intercourse becomes painful or difficult, you should consult your doctor for treatment.