Navigating Psoriasis With Otezla: What You Need to Know

Understanding Psoriasis and Otezla

Psoriasis is a chronic inflammatory skin condition that causes itchy, red, and scaly patches on the skin. The exact cause of psoriasis is unknown, but it is thought to be related to the body's immune system and genetic factors.

Otezla (apremilast) is an oral medication used to treat moderate to severe plaque psoriasis in adults. It belongs to a class of medications called phosphodiesterase 4 (PDE4) inhibitors, which work by reducing inflammation in the body.

How Otezla Works

Otezla works by inhibiting the activity of an enzyme called phosphodiesterase 4 (PDE4). This enzyme is involved in the production of inflammatory molecules, such as tumor necrosis factor-alpha (TNF-alpha) and interleukin-17 (IL-17). By inhibiting PDE4, Otezla reduces the production of these inflammatory molecules, which helps to improve psoriasis symptoms.

Otezla Dosage and Administration

Otezla is taken orally, usually twice a day. The starting dose is typically 30 mg once a day for the first week. This is increased to 30 mg twice a day for the second week. The usual maintenance dose is 30 mg twice a day.

Otezla Side Effects

The most common side effects of Otezla include:

* Nausea

* Diarrhea

* Headache

* Fatigue

* Upper respiratory tract infection

* Back pain

* Muscle pain

* Increased blood pressure

* Weight gain

* Mood changes

* Suicidal thoughts

Otezla Warnings and Precautions

Otezla should not be used by people with a history of severe liver disease or kidney disease. It should also be used with caution in people with a history of depression, suicidal thoughts, or other mental health conditions.

Otezla Drug Interactions

Otezla may interact with other medications, including:

* Cyclosporine

* Methotrexate

* Leflunomide

* Tacrolimus

It is important to tell your doctor about all of the medications you are taking, including prescription drugs, over-the-counter drugs, vitamins, and herbal supplements, before starting Otezla.

Otezla and Pregnancy

Otezla should not be used during pregnancy. It is not known whether Otezla can harm an unborn baby.

Otezla and Breastfeeding

Otezla should not be used while breastfeeding. It is not known whether Otezla can pass into breast milk and harm a nursing infant.

Monitoring for Otezla Side Effects

Your doctor may monitor you for side effects of Otezla, such as changes in blood pressure, weight, and mood. You should report any new or worsening side effects to your doctor right away.

Conclusion

Otezla is an effective medication for treating moderate to severe plaque psoriasis in adults. However, it is important to be aware of the potential side effects of Otezla and to talk to your doctor about whether this medication is right for you.