Tetanus toxoid and anti-tetanus serum are given same time however they not administered at the site.why?

Tetanus toxoid and anti-tetanus serum are given at the same time in cases of tetanus prophylaxis, but they are not administered at the same site. This is because the toxoid and the antiserum work in different ways and administering them at the same site can interfere with their efficacy.

Tetanus toxoid is a vaccine that stimulates the body to produce antibodies against tetanus toxin. These antibodies can neutralize the toxin and prevent it from causing tetanus. Tetanus toxoid is typically given as a series of injections over the course of several weeks.

Anti-tetanus serum is a preparation that contains antibodies against tetanus toxin. These antibodies can neutralize the toxin and prevent it from causing tetanus. Anti-tetanus serum is typically given as a single injection.

If tetanus toxoid and anti-tetanus serum are administered at the same site, the antibodies in the antiserum can bind to the toxoid and prevent it from being recognized by the immune system. This can reduce the efficacy of the toxoid and increase the risk of tetanus.

For this reason, tetanus toxoid and anti-tetanus serum are always administered at different sites. The toxoid is typically given in the deltoid muscle of the upper arm, and the anti-tetanus serum is typically given in the gluteus maximus muscle of the buttock.