Ankylosing Spondylitis and the Connection?

Ankylosing spondylitis (AS) is a type of inflammatory arthritis that affects the spine and other joints. It is part of a group of conditions known as spondyloarthritis, which also includes psoriatic arthritis, reactive arthritis, and enteropathic arthritis. AS is characterized by inflammation of the sacroiliac joints, which are located at the base of the spine, and the spine itself. It can also cause inflammation in other joints, such as the shoulders, hips, and knees.

AS is associated with a number of other conditions, including:

* Psoriasis: Psoriasis is a skin condition that causes red, scaly patches on the skin. About 30% of people with AS also have psoriasis.

* Inflammatory bowel disease (IBD): IBD is a group of conditions that cause inflammation of the digestive tract. About 10% of people with AS also have IBD.

* Uveitis: Uveitis is an inflammation of the eye. About 20% of people with AS also have uveitis.

* Amyloidosis: Amyloidosis is a condition that occurs when a protein called amyloid builds up in the body. Amyloidosis can cause a number of health problems, including kidney failure, heart failure, and nerve damage. About 1% of people with AS also develop amyloidosis.

The exact cause of AS is unknown, but it is thought to be related to a combination of genetic and environmental factors. Genes that play a role in the immune system are thought to be involved in the development of AS. Certain environmental factors, such as infection, may also trigger the development of AS.

There is no cure for AS, but treatment can help to manage the symptoms and prevent long-term complications. Treatment options include medications, physical therapy, and surgery.