Permanent destructive enlargement of airspaces distal to the terminal bronchioles is most expected in a patient diagnosed with?

The answer is emphysema.

Emphysema is a chronic lung disease that causes shortness of breath. It is caused by damage to the alveoli, the small air sacs in the lungs. This damage can be caused by smoking, air pollution, or other factors. Emphysema is a progressive disease, meaning that it gets worse over time. There is no cure for emphysema, but treatment can help to relieve symptoms and slow the progression of the disease.