Can pioglitazone cause pedal oedema on prolonged use?

Yes, pioglitazone can cause pedal oedema on prolonged use.

Pioglitazone, manufactured by Takeda, is a thiazolidinedione antihyperglycaemic agent used in the treatment of type 2 diabetes. It causes dose-dependent peripheral oedema due to fluid retention in the subcutaneous spaces of the hands and feet. This usually responds to dose reduction.