What the Prognosis and natural history of rheumatoid arthritis?
Prognosis- Approximately 20% to 30% of patients with rheumatoid arthritis (RA) experience a complete remission of symptoms, usually within the first 2 years of disease onset.
- Most patients with RA experience a relapsing-remitting course, with periods of disease activity alternating with periods of remission.
- Approximately 10% to 20% of patients with RA develop a progressive, erosive disease course that leads to significant joint damage and disability.
- The prognosis of RA is influenced by a number of factors, including:
- Age at disease onset
- Disease severity
- Presence of extra-articular manifestations
- Response to treatment
Natural history
The natural history of RA can be divided into four stages:
1. Early stage (0-6 months): This stage is characterized by inflammation of the synovial joints, leading to pain, swelling, and stiffness.
2. Established stage (6 months to 2 years): During this stage, the inflammation becomes more widespread and may affect multiple joints. Joint damage begins to occur, and patients may experience fatigue, weight loss, and other systemic symptoms.
3. Late stage (2-10 years): This stage is characterized by progressive joint damage and disability. Patients may experience difficulty walking, dressing, and performing other activities of daily living.
4. Terminal stage (10+ years): This stage is characterized by severe joint damage and disability. Patients may require assistance with all activities of daily living and may be unable to leave their homes.