Can MDMA cause twitching in sleep?

Yes, MDMA can cause twitching during sleep. MDMA has been found to disrupt the brain's production of serotonin and other neurotransmitters, both of which are linked to sleep regulation, sleep quality and sleep onset. Furthermore, MDMA may disrupt the body's natural sleep-wake cycle, making twitching, tossing, and turning during sleep more likely.