Urinary sodium excretion is higher after losartan?

Urinary sodium excretion is higher after lisinopril, not losartan. Lisinopril is an ACE inhibitor, while losartan is an angiotensin receptor blocker (ARB). Both ACE inhibitors and ARBs are used to treat high blood pressure, but they work in different ways. ACE inhibitors work by blocking the conversion of angiotensin I to angiotensin II, while ARBs work by blocking the binding of angiotensin II to its receptors.

One of the effects of ACE inhibitors is to increase urinary sodium excretion. This is because ACE inhibitors cause the blood vessels to relax, which leads to a decrease in blood pressure. In response to the decrease in blood pressure, the body releases renin, which in turn causes the kidneys to retain sodium and water. ACE inhibitors counteract this effect by blocking the conversion of angiotensin I to angiotensin II, which prevents the kidneys from retaining sodium and water. As a result, urinary sodium excretion increases.

ARBs, on the other hand, do not have the same effect on urinary sodium excretion as ACE inhibitors. This is because ARBs do not block the conversion of angiotensin I to angiotensin II, so the kidneys do not retain sodium and water in response to a decrease in blood pressure. As a result, urinary sodium excretion is not affected by ARBs.