What problems did the plague for Issac Newton?

The plague did not cause any particular problems for Isaac Newton personally.

Isaac Newton was born on Christmas Day 1642 during a period of civil unrest in England known as the English Civil War. The great plague of London, which was one of the deadliest pandemics in Britain, occurred in 1665-1666, when Newton was 23-24 years old. During this period, Cambridge University closed for two years, forcing Newton to return to his home in Woolsthorpe Manor, Lincolnshire.

Newton's time in Woolsthorpe Manor proved to be a highly productive period, known as his "annus mirabilis" or "year of wonders". Isolated from the distractions of university life, Newton made significant breakthroughs in mathematics, optics, and physics, including the development of calculus, his work on the law of universal gravitation, and his theory of optics and color.

While the plague certainly impacted England and the University of Cambridge, there is no evidence to suggest that it directly affected Isaac Newton in a negative way. Instead, it provided an opportunity for him to focus on his studies and achieve great intellectual achievements.