| | Conditions Treatments | Viruses When was the plague documented? The plague is first documented in historical records during the 6th century AD in Eastern Europe, where the plague of Justinian caused an estimated 30-50 million deaths. Viruses - Related Articles What Is Glucose Tolerance? Reasons for Lower Stomach Pain Natural UTI Treatment What is ophthalmocentesis? How to Alleviate Itching How to Take Butcher's Broom for Health Homemade Splints