How does polio virus affect immune system?

Poliovirus can affect the immune system in a number of ways.

* Direct infection of immune cells. Poliovirus can directly infect and damage immune cells, such as T cells and B cells. This can lead to a decrease in the number of immune cells and a decrease in the ability of the immune system to respond to infections.

* Impairment of immune function. Poliovirus can also impair the function of immune cells, even if they are not directly infected. For example, poliovirus can inhibit the production of antibodies and cytokines, which are important molecules for the immune response.

* Induction of autoimmunity. In some cases, poliovirus infection can lead to the development of autoimmunity, a condition in which the immune system attacks the body's own tissues. This can occur when the immune system is damaged or dysregulated by poliovirus infection.

The effects of poliovirus on the immune system can vary depending on the strain of the virus and the individual's immune status. In most cases, poliovirus infection does not lead to long-term damage to the immune system. However, in some cases, poliovirus infection can lead to serious complications, such as paralytic poliomyelitis, which can result in permanent paralysis.