What is the risk of parental age on causation cleft lip?

Advanced parental age is a well-known risk factor for several genetic conditions, including cleft lip with or without cleft palate (CL/P). The risk of having a child with CL/P increases with the age of both the mother and the father, especially for mothers over the age of 35 and fathers over the age of 40.

The exact mechanism by which advanced parental age increases the risk of CL/P is not fully understood, but it is thought to be due to a combination of factors, including:

* Changes in the quality of gametes (eggs and sperm): As people age, the quality of their gametes decreases. This is due to an increased number of mutations and chromosomal abnormalities that occur during gamete formation.

* Changes in hormonal levels: Advanced parental age is associated with changes in hormonal levels, which can affect the development of the fetus.

* Environmental factors: Older parents are more likely to have been exposed to environmental factors that can increase the risk of CL/P, such as certain medications, alcohol, and tobacco smoke.

The risk of CL/P associated with advanced parental age is small, but it is important to be aware of it when considering family planning. If you are over the age of 35 and planning to have a child, it is important to talk to your doctor about your risks and options.

Here are some additional factors that can increase the risk of CL/P:

* Family history of CL/P: If you have a family history of CL/P, your risk of having a child with the condition is increased.

* Race/ethnicity: CL/P is more common in certain racial/ethnic groups, including Asian, Hispanic, and Native American populations.

* Certain medical conditions: Some medical conditions, such as diabetes, obesity, and certain medications, can increase the risk of CL/P.

If you are concerned about your risk of having a child with CL/P, talk to your doctor. They can help you assess your risks and make informed decisions about family planning.