Can you eat grapefruit while taking Sotalol?
It is not recommended to consume grapefruit or grapefruit juice while taking Sotalol.
Grapefruit can significantly inhibit a CYP3A4 intestinal enzyme, which is primarily responsible for metabolizing sotalol in the body. This inhibitory effect can lead to increased blood concentrations of sotalol, potentially intensifying its therapeutic effects and increasing the risk of adverse reactions.
The heightened sotalol levels resulting from grapefruit consumption can prolong the medication's action on the heart and potentially cause life-threatening arrhythmias, such as torsades de pointes (TdP). This irregular heartbeat can be severe, leading to symptoms like fainting, dizziness, shortness of breath, or chest pain.
As a precaution, it is advised to avoid consuming grapefruit, grapefruit juice, or other citrus fruits known to inhibit CYP3A4 while taking sotalol. If you have any questions or concerns, make sure to consult your doctor or pharmacist for further advice and personalized recommendations.
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