Significance of the Acetyl Coenzyme A Degradation Pathway

Acetyl Coenzyme A is a metabolite intermediate in the biochemical processes that occur within the human body. Acetyl CoA comes from various cycles including glycolysis, fatty acid oxidation and break down of amino acids. Acetyl CoA is an important contributor to lipid biosynthesis.
  1. Degradation

    • Degradation of Acetyl CoA results in acetate + ATP + coenzyme A. ATP is a form of energy used in the body to make bonds between molecules. Acetate is a derivative from acetic acid. Coenzyme A is an enzyme that helps accelerate the bond formation between molecules, depending on how favorable the reaction is in the body.

    Acetate

    • Acetate is derived from acetic acid in the body. The purpose of acetate is to donate an acyl group to another molecule to make acetyl CoA. Unused acetate gets filtered through the kidneys and excreted through urine.

    Coenzyme A

    • Coenzyme A, like many enzymes, is used to complete a reaction in the body. The unique thing about enzymes is that they are reusable. This means if the body has enough energy in the form of ATP and acetate, the reaction can proceed to making the product Acetyl CoA.

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