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Is 5-HTP Safe?

5-HTP is used by patients suffering from conditions stemming from low levels of serotonin. It is important to take note of certain interferences and to consult your doctor before taking 5-HTP to ensure you are using it safely.

  1. Significance

    • 5-HTP, or 5-hydroxytryptophan, is produced by your body from tryptophan, an amino acid found in foods. If you suffer from serotonin deficiency, 5-HTP can help you overcome the effects of low serotonin, such as depression, appetite changes and insomnia.

    History

    • L-tryptophan, a manufactured amino acid, is a dietary supplement that raises serotonin levels and was used in the United States as treatment for depression, insomnia and obesity. L-tryptophan was recalled in the late 1980s due to patients suffering from high fever, swelling and shortness of breath. 5-HTP is an alternative to L-tryptophan that provides the same benefits without the risks.

    Serotonin Syndrome

    • It is possible for serotonin levels to get too high. This is called serotonin syndrome and can cause fever, shivering and diarrhea. Do not take 5-HTP if you are taking a prescription MAO inhibitor, as the combination can raise your serotonin levels too much.

    Side Effects

    • Nausea can be a side effect of taking 5-HTP. You can avoid this by starting at 50mg per day and increasing to 100 mg per day after two weeks. Also, take 5-HTP with food.

    Parkinson's Disease

    • 5-HTP can be beneficial as a supplement for Parkinson's disease, in addition to other standard treatments. It should not be used as the only treatment, because it can worsen symptoms. If you have Parkinson's disease and are taking Eldepryl, do not take 5-HTP, because it can cause serotonin to become too high.

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