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Side Effects of Acetyl-L-Carnitine

Acetyl-l-carnitine is also known as ALC, l-acetyl-carnitine, and acetylcarnitine. It is a molecule occurring naturally in the liver, kidney and brain. It is also available as a dietary supplement. Acetyl-l-carnitine is used for age-related cognitive decline and for a variety of other health concerns. Side effects are rare but can occur, and there can be drug interactions.

  1. Definition

    • According to the Maimonides Medical Center, acetyl-l-carnitine is similar in form to l-carnitine, an amino acid. It also has functions similar to l-carnitine, such as being helpful in the metabolizing of food into energy. Acetyl-l-carnitine is part of the acetyl group that contributes to the production of the neurotransmitter acetylcholine, a requirement for mental function.

    Benefits/Uses

    • The Maimonides Medical Center reports that there are benefits to using acetyl-l-carnitine in the treatment of age-related cognitive decline; scientific data has shown reliable and relatively consistent substantial health benefits in this area. Acetyl-l-carnitine has also shown some benefits in the treatment of Alzheimer's disease, Down syndrome, depression (for the elderly), fibromyalgia, liver cirrhosis, type 1 diabetes, type 2 diabetes, erectile dysfunction (in combination with l-carnitine) and macular degeneration (when used with fish oil).

    Side Effects

    • According to PeaceHealth, when using acetyl-l-carnitine, side effects are uncommon, however, some can occur. Side effects including an increase in appetite, nausea and vomiting, agitation, skin rash and body odor have been reported.

    Interactions

    • PeaceHealth reports that certain drug interactions can occur when taking acetyl-l-carnitine. Drug interactions have occurred with Cisplatin, Didanosine, Paclitaxel and Stavudine. Some drug interactions may cause the need to increase the intake of acetyl-l-carnitine.

    Dosages

    • The Maimonides Medical Center reports that most research involving acetyl-l-carnitine recommends using 500 mg three times daily. Some research has used twice this amount for beneficial results. Acetyl-l-carnitine levels are known to decrease with advancing age. However, it is not an essential nutrient and therefore, no true deficiency occurs.

    Warning

    • The Food and Drug Administration (FDA) considers all herbs, vitamins and minerals to be dietary supplements; they are not subject to the same quality control as prescription medication. Some supplements may interact with your prescription medicine. Consult with your health care provider before adding a new supplement to your diet.

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