Metabolism & Lexapro

Lexapro is a selective serotonin reuptake inhibitor (SSRI) used to treat Major Depression Disorder (MDD) and Generalized Anxiety Disorder (GAD). While Lexapro is well tolerated by most people, there have been reports of adverse reactions, including dry mouth, increased sweating, fatigue and changes in metabolism.

Changes in Metabolism

• According to a study conducted by Forest Laboratiories, Inc. in 2004, adverse metabolic reactions included hypoglycemia, hyperglycemia, hypokalemia and hyponatremia.

Hyperglycemia

• Too much sugar

  Hyperglycemia is a condition caused by an elevation of blood glucose levels. When the level of glucose in the blood is excessive--more than the body needs for energy--excess sugar is stored as fat.

Hypoglycemia

• Not enough sugar

  Hypoglycemia, on the other hand, occurs when blood sugar is low. Low blood sugar causes the body to go into storing mode, resulting in more sugar stored than converted to glycogen--sugar in the form of fuel--for energy.

Hypokalemia

• Potassium depletion

  Hypokalemia results from low blood potassium levels (K+). Dramatic changes in blood potassium compromises the nervous system and normal function of the heart. In extreme cases, it can even be fatal.

Hyponatremia

• Too little salt

  Hyponatremia results from a low concentration of sodium in the blood, a condition often linked to diuretics and antidepressants, in addition to hypothyroidism and cortisone deficiencies, such as in Addison's disease. Symptoms include bloating, vomiting, headache, disorientation and muscle weakness.

Counterproductive to Curbing Depression

• Weight gain got you down?

  Due to these adverse metabolic affects, it has been suggested that Lexapro and other anti-depressants may actually increase depression. Patients are advised to talk to their doctors about alternative treatments, if they experience such reactions.