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What is Pyruvate?

Pyruvate is also known as pyruvic acid. It occurs naturally in the body but is not considered an essential nutrient. Reliable data has shown pyruvate to be beneficial as a dietary supplement when used for weight loss and obesity. It has also been used to improve athletic performance. There are no well-known drug interactions and side effects appear to be minor.

  1. Definition

    • According to PeaceHealth, pyruvate is also known as the buffered form of pyruvic acid. Pyruvic acid is a product created by the body while metabolizing protein and carbohydrates. It is found in a variety of foods, including dark beer, red wine, red apples and cheese. Pyruvate is available in dietary supplement form.

    Weight Control Features

    • Pyruvate supplements are used for weight loss and obesity. According to PeaceHealth, relatively consistent and reliable scientific data has shown pyruvate to provide a substantial health benefit. In a six-week double-blind trial, as little as 6 g per day, along with exercise, led to greater loss of weight and body fat compared to a placebo with exercise.

    Dosages

    • According to the University of Maryland Medical Center, pyruvate has shown some evidence in reducing body fat. It is believed to be possible by increasing the body's metabolic rate. The recommended dosage is 22 to 44 g per day. PeaceHealth reports that for weight loss at least 30 g per day is recommended.

    Athletic Performance Features

    • For exercise performance, PeaceHealth reports that contradictory, insufficient or preliminary studies suggest a health benefit or a minimal health benefit. To improve body composition with strength training in untrained people, the supplement has shown little scientific support or minimal health benefit.

    Side Effects

    • PeaceHealth reports that side effects can occur with improper intakes. High dosages of pyruvate can trigger gastrointestinal upsets; this includes bloating, gas and diarrhea. A preliminary study of exercising women found that as little as 10 g of pyruvate taken daily can reduce blood levels of HDL ("good" cholesterol) after a month.

    Clinical Opinion

    • According to the Mayo Clinic, when taken as a supplement, pyruvate appears to be safe. It may also help with weight loss. However, taking more than 5 g per day may cause gas, bloating and diarrhea.

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