Is depakote more prone to gain weight than ER?

Yes, Depakote is more likely to cause weight gain than Depakote ER (extended release). The likelihood of weight gain with Depakote is estimated to be around 10-20%, while the risk with Depakote ER is approximately 5-10%. This difference is because Depakote ER is absorbed more slowly and maintains a steady level of medication in the body, leading to a reduced chance of weight gain. Additionally, Depakote ER may have a more favorable impact on metabolism compared to Depakote. However, it's important to note that weight gain can still occur with either medication, and individual responses may vary. If you are concerned about weight gain while taking Depakote or Depakote ER, discuss it with your healthcare provider.